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Abstract #5013

Improved tumor characterization with direct saturation corrected (DISC) amide proton transfer (APT) MRI in glioma patients

Yin Wu1, Yinsheng Chen2, Jie Liu1, Cong Li2, Xiaofei Lv3, Zhongping Chen2, Phillip Zhe Sun4,5, and Hairong Zheng1

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Neurosurgery, Cancer Center, Sun Yat-Sen University, Guangzhou, China, 3Department of Medical Imaging, Cancer Center, Sun Yat-Sen University, Guangzhou, China, 4Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 5Department of Radiology, Emory University School of Medicine, Atlanta, GA, United States

Recently, a direct saturation correction (DISC) method has proved to improve APT quantification in pulsed-RF CEST imaging. In this study, performance of tumor characterization was compared among routine asymmetry analysis (MTRasym), three-point offset (APT3pts) and the DISC methods in glioma patients at 3T. Although all methods revealed significant APT elevation in tumor region compared to that in the contralateral normal appearing white matter, the DISC method exhibited substantially higher contrast-to-noise ratio (2.16±0.90) between the two regions than that of MTRasym (1.78±1.08) and APT3pts (0.87±0.57), demonstrating its superiority in improved sensitivity for tumor characterization.

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