Abstract #5014

Quantifying the Effects of Pulsed Saturation Transfer at 1.5T and 3T

Rachel W. Chan¹, Sten Myrehaug^2,3, Greg J. Stanisz^1,4,5, Arjun Sahgal^1,2,3, and Angus Z. Lau^1,4

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Department of Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin, Poland

The aim of this study was to investigate the feasibility of CEST imaging at 1.5T and to compare the results to 3T experiments. CEST and MT parameters were quantified in phantoms and in the healthy brain at both fields. A pulsed saturation scheme was used to overcome the single RF amplifier duty cycle limitations of the 1.5T clinical scanner. Parameters were estimated using a Bloch-McConnell two-pool simulation that incorporated the extended phase graph formalism. The new methods demonstrated promise for enabling broader application of CEST MRI for field strengths below 3T.

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