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Abstract #5017

Fully Steady-State Chemical Exchange Saturation Transfer (CEST) imaging for Amide Proton Transfer (APT) at 3T MRI

Byungjai Kim1, Seohee So1, Namho Jeong1, and Hyunwook Park1

1Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of

A steady-state chemical exchange saturation transfer (SS-CEST) MRI, which is based on the standard macromolecule transfer (MT) imaging method, has been developed for fast scanning 1,2. In this study, we proposed a SS-CEST imaging combined with steady-state free precession (SSFP) which is so-called fully SS-CEST imaging. The fully SS-CEST method was compared with a SS-CEST combined with spoiled gradient echo (SPGR) through numerical simulations and MRI experiments. The results show that the fully SS-CEST method can provide higher amide proton transfer (APT) contrast than the SS-CEST with SGPR.

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