Abstract #5016

Comparison between glucoCEST at 3T and Blood Glucose Sampling in Humans

Anina Seidemo¹, Anna Rydhög², Ronnie Wirestam¹, Xiang Xu^3,4, Akansha Ashvani Sehgal^3,4, Yi Zhang⁵, Frederik Testud⁶, Pia C Sundgren^2,7,8, Peter C van Zijl^3,4, and Linda Knutsson^1,3

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Centre for Medical Imaging and Physiology, Skåne University Hospital, Lund and Malmö, Sweden, ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁵College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ⁶Siemens Healthcare AB, Malmö, Sweden, ⁷Institution of Clinical Sciences/Diagnostic Radiology, Lund University, Lund, Sweden, ⁸Lund University Bioimaging Center, Lund University, Lund, Sweden

Dynamic glucose-enhanced (DGE) MRI uses chemical exchange saturation transfer (CEST) to retrieve information about microcirculation using D-glucose as a contrast agent.We performed glucoCEST imaging in four healthy volunteers at 3T and compared arterial input functions (AIFs) and DGE signal in white matter to measured venous blood glucose levels after glucose infusion. An increase in DGE signal following the glucose infusion was observed in cerebral arteries, but not in white matter. We observed a similarity in shape of the AIF and the blood glucose curve, and that a higher blood glucose level corresponds to a higher DGE signal.

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