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Abstract #5016

Comparison between glucoCEST at 3T and Blood Glucose Sampling in Humans

Anina Seidemo1, Anna Rydhög2, Ronnie Wirestam1, Xiang Xu3,4, Akansha Ashvani Sehgal3,4, Yi Zhang5, Frederik Testud6, Pia C Sundgren2,7,8, Peter C van Zijl3,4, and Linda Knutsson1,3

1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Centre for Medical Imaging and Physiology, Skåne University Hospital, Lund and Malmö, Sweden, 3Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, 6Siemens Healthcare AB, Malmö, Sweden, 7Institution of Clinical Sciences/Diagnostic Radiology, Lund University, Lund, Sweden, 8Lund University Bioimaging Center, Lund University, Lund, Sweden

Dynamic glucose-enhanced (DGE) MRI uses chemical exchange saturation transfer (CEST) to retrieve information about microcirculation using D-glucose as a contrast agent.We performed glucoCEST imaging in four healthy volunteers at 3T and compared arterial input functions (AIFs) and DGE signal in white matter to measured venous blood glucose levels after glucose infusion. An increase in DGE signal following the glucose infusion was observed in cerebral arteries, but not in white matter. We observed a similarity in shape of the AIF and the blood glucose curve, and that a higher blood glucose level corresponds to a higher DGE signal.

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