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Abstract #5020

Investigating Variability Sources in Kidney Perfusion Measurements with Pulsed ASL: A Phantom and In Vivo Pilot Study

Jorge Chacon-Caldera1, Lisa-Maria Hatz1, Anja Kruse1, Tanja Uhrig1, Fabian Zimmer1, Simon Hubertus1, Ingo Hermann1, Lothar R. Schad1, and Frank G Zöllner1

1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Mannheim, Germany

In this work, the variations of a 3D GRASE sequence with a fast pulsed ASL protocol at 3T were tested in isolation using a phantom and in vivo measurements. In vivo, 25 single scans in breath hold with a single volunteer were obtained in one session, thus reducing breathing motion and registration uncertainties as well as shimming, inter-volunteer and hydration stage variabilities. In phantom, we found a perfusion of 94.5 ± 5.4 ml/min/100g and in vivo, we found perfusion values in the expected physiological range with high standard deviation inter-scans but high correlation between kidneys. This suggests physiological instead of signal-to-noise related variations which would yield random inter-kidney variations.

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