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Abstract #5021

A Split-Label Design for Simultaneous Measurements of Perfusion in Distant Slices by Pulsed Arterial Spin Labeling

Celine Baligand1, Lydiane Hirschler1, Thom T.J. Veeger1, Suzanne L. Franklin1, Matthias J.P. van Osch1, and Hermien E. Kan1

1C.J. Gorter Center for high field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Most Arterial-Spin-Labeling (ASL-)MRI in exercised muscle employ single-slice acquisitions. However, fiber-type and oxidative capacity vary along the length of healthy muscles. Therefore, multi-slice acquisitions are desirable. Multi-slice pulsed ASL coverage is limited because the label is created proximally from the stack of slices. In muscle, this implies long transit times to the most distal slice due to slow flow. We propose a split-label design adaptation of FAIR that allows for sufficient labeling for distant slices. We validated our approach in the brain to take advantage of the high resting-state perfusion, and applied it in the lower leg muscle after exercise.

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