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Abstract #5024

Quantification of Multiple Boli Arterial Spin Labelling in Mice and Rats

Samantha Paterson1, Camille Graff2, Antoine Vallatos3, and William Holmes1

1Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom, 2Grenoble INP, Grenoble, France, 3University of Edinburgh, Edinburgh, United Kingdom

A need for high SNR quantitative ASL has driven the quantification of mbASL, a high SNR ASL sequence that uses adiabatic pulses to label multiple boli of arterial water. The sequence has a hybrid PASL & CASL nature with a modified Buxton kinetic model used to describe this hybrid-like nature. We have shown that experimental results mirror theoretical predictions with signal distribution changing with labelling slice thickness. High SNR mbASL images in mice and rats with significantly higher signal than the standard FAIR sequence have been produced and CBF images and values acquired that agree with the literature.

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