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Abstract #5025

Imaging Blood Brain Barrier Permeability in a Human African Trypanosomiasis Mouse Model using Diffusion Weighted Multiple Boli Arterial Spin Labelling

Samantha Paterson1, Antoine Vallatos2, Jean Rodgers3, and William Holmes1

1Neuroscience & Psychology, University of Glasgow, Glasgow, United Kingdom, 2University of Edinburgh, Edinburgh, United Kingdom, 3University of Glasgow, Glasgow, United Kingdom

Human African Trypanosomiasis is a parasitic disease that causes progressive blood brain barrier breakdown. We have developed a non-invasive high SNR ASL technique (mbASL) combined with bipolar diffusion gradients to determine the ratio of intravascular to extravascular signal from the brain. The ratio of this signal will change in a mouse brain infected with HAT due to the barrier breakdown. We have imaged this changing brain along with producing CBF maps, thus using a novel method in imaging a HAT infected mouse.

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