Meeting Banner
Abstract #5034

Repeatability of hepatocellular uptake and efflux in the rat liver: A comparison of Gadoxetate DCE-MRI models

Sirisha Tadimalla1, Claudia Green2, Denise Steinmann3, Sascha Koehler4, Hans-Paul Juretschke3, Iina Laitinen3, John C Waterton5,6, Paul D Hockings7,8, Catherine D Hines9, Gunnar Schütz2, and Steven Sourbron1

1Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, 2MR & CT Contrast Media Research, Bayer AG, Berlin, Germany, 3R&D TIM Bioimaging Germany, Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany, 4Bruker BioSpin MRI GmbH, Ettlingen, Germany, 5Bioxydyn Ltd, Manchester Science Park, United Kingdom, 6Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom, 7Antaros Medical, BioVenture Hub, Mölndal, Sweden, 8Chalmers University of Technology, MedTech West, Gothenburg, Sweden, 9Merck & Co., West Point, PA, United States

A variety of Gadoxetate DCE-MRI models have been proposed to derive hepatocyte uptake and efflux rates in the rat, but it is unclear which provides most reliable measurements. Here, we compare four models in terms of their test-retest repeatability on 9 rats measured in 3 sites. Results indicate that a two-compartment high-flow model, assuming negligible sinusoidal backflux and a fixed population-based extracellular volume fraction, provides most repeatable measures of hepatocellular function in the healthy rat.

This abstract and the presentation materials are available to members only; a login is required.

Join Here