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Abstract #5035

Pharmacokinetic Parameter Accuracy Correlates with Image Quality Metrics in Flexible Temporal Resolution DCE-MRI Simulations

Allister Mason1,2, Nathan Murtha3, James Rioux1,2,4, Sharon Clarke2,4, Chris Bowen1,2,4, and Steven Beyea1,2,4

1Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada, 2Biomedical Translational Imaging Centre (BIOTIC), Nova Scotia Health Authority, Halifax, NS, Canada, 3Physics, Carelton University, Ottawa, ON, Canada, 4Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada

The choice of imaging parameters in dynamic contrast enhanced (DCE) MRI, such as temporal resolution, can affect the recovered parameter when using quantitative pharmacokinetic (PK) models, such as Ktrans in the Tofts model. We propose objective image quality metrics (IQMs) as a tool to guide this choice to maximize PK parameter accuracy. DCE MRI simulations were performed on a numerical phantom with user defined PK parameters. IQMs were calculated using the numerical phantom as a reference and references generated from the simulated data. In both cases, a strong correlation between the PK parameter error and IQM score is found.

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