Abstract #5036

The role of perivascular spaces in white matter dynamic susceptibility contrast MRI

Jonathan Doucette^1,2, Enedino Hernández-Torres^1,3, Christian Kames^1,2, and Alexander Rauscher^1,3,4

¹UBC MRI Research Centre, Vancouver, BC, Canada, ²Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ³Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁴Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Using vascular parameters obtained from dynamic susceptibility contrast MRI, the gradient echo (GRE) and spin echo (SE) dynamic susceptibility contrast (DSC) induced changes in $$$\Delta{R_2^{(*)}}$$$ were simulated at 3T in order to investigate the effects of tissue orientation and perivascular spaces (PVS). We found that the orientation dependence of both $$$\Delta{R_2}$$$ and $$$\Delta{R_2^*}$$$ are amplified by PVS, though $$$\Delta{R_2}$$$ is far more sensitive to PVS.

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