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Abstract #5038

A novel trimodality vascular contrast agent for “image-based systems biology” applications

Akanksha Bhargava1, Priyanka Kushwaha 2, Ryan C. Riddle2, Manisha Aggarwal1, and Arvind P. Pathak1

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Preclinical vascular imaging has been instrumental in advancing our understanding of the role of blood vessels in health and disease. However, currently there are no vascular contrast agents that are simultaneously visible with all three primary imaging modalities, i.e. MRI, CT and optical imaging. Consequently, this poses a hurdle when integrating multiscale, multimodality vascular imaging data for systems biology applications. Therefore, we developed a new vascular contrast agent that delivers trimodal imaging capabilities with MRI, CT and optical imaging for preclinical systems biology investigations. We demonstrate its compatibility with different types of imaging contrasts that allow trimodality, multiscale imaging of healthy (e.g. murine brain, leg, kidney) and pathological microvasculature (e.g. cancer xenografts).

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