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Abstract #5039

Using D2O As a Diffusible Tracer in Characterizing Tumor Properties on Mice

Pei-Lun Yu1, Ming Cheng1, Xiayu Lyu1, Sheng-Min Huang1, Kung-Chu Ho2, and Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Division of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

As a diffusible tracer, D2O was employed as a negative contrast agent in investigating tumor perfusion in this study. Results show that the transfer constant derived from D2O perfusion is able to characterize tumor flow properties. Furthermore, we also demonstrated that the initial area under curve of D2O perfusion has potential in detecting the flow difference between tumor and normal tissue, suggesting the feasibility of semi-quantitative indices for D2O perfusion.

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