Abstract #5041

Using multi-bolus injection protocol to improve the robustness of DCE-MRI: application in rabbit liver

Sofia Veneti^1,2, Daniel BALVAY^1,3, Gwennhäel AUTRET^1,3, and Charles A CUENOD^1,2,4

¹Paris Cardiovascular Research Center (PARCC), Paris, France, ²Paris Descartes University, Paris, France, ³Plateforme d'Imagerie du Vivant de Paris Descartes, Paris, France, ⁴Hospital Europeen G.Pompidou (HEGP)-APHP, Paris, France

Quantitative DCE-MRI suffers from limitations in the liver due to its dual input (hepatic artery, portal vein). Single- and multi-bolus (four) injection protocols were performed in rabbits on a 4.7T small-animal MRI. The Hepatic Perfusion Index (HPI), total hepatic blood flow (F), and distribution volume (Vd) were studied using a computer simulation and evaluated by the Coefficient of Variation (CV) and the 95% Confidence Interval (CI) factors. Statistical tests were performed for 1000 iterations with Mann-Whitney test and p<0.002 statistically significant. Multi-bolus injection protocol strongly improve the DCE precision in the liver particularly for HPI, which is a critical parameter.

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