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Abstract #5042

Measuring Regional Gas Transport in Injured Rabbit Lungs Using Hyperpolarized Xenon

Yi Xin1, Kai Ruppert1, Maurizio Cereda2, Faraz Amzajerdian1, Hooman Hamedania1, Mehrdad Pourfathi1, Sarmad Siddiqui1, Ian Duncan1, Luis Loza1, Tahmina Achekzai1, Federico Sertic1, Ryan Baron1, Harrilla Profka1, Stephen Kadlecek1, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Hyperpolarized 129-Xenon MRI measures the regional content of tracer gas in the lungs; it can also differentiate between Xenon contained in the gas phase (GP) and in the dissolved phase (DP), allowing us to characterize regional gas diffusivity and uptake in the pulmonary capillary blood in addition to capturing parameters of alveolar aeration. By measuring absorbed Xenon signal in the left heart and aorta shortly after inhalation, it is theoretically possible to study the next step of gas transfer by measuring the gas that reaches the arterial blood. In this study, we explore the regional gas transport of injured rabbit lungs in two different states of recruitment.

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