Abstract #5042

Measuring Regional Gas Transport in Injured Rabbit Lungs Using Hyperpolarized Xenon

Yi Xin¹, Kai Ruppert¹, Maurizio Cereda², Faraz Amzajerdian¹, Hooman Hamedania¹, Mehrdad Pourfathi¹, Sarmad Siddiqui¹, Ian Duncan¹, Luis Loza¹, Tahmina Achekzai¹, Federico Sertic¹, Ryan Baron¹, Harrilla Profka¹, Stephen Kadlecek¹, and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Hyperpolarized 129-Xenon MRI measures the regional content of tracer gas in the lungs; it can also differentiate between Xenon contained in the gas phase (GP) and in the dissolved phase (DP), allowing us to characterize regional gas diffusivity and uptake in the pulmonary capillary blood in addition to capturing parameters of alveolar aeration. By measuring absorbed Xenon signal in the left heart and aorta shortly after inhalation, it is theoretically possible to study the next step of gas transfer by measuring the gas that reaches the arterial blood. In this study, we explore the regional gas transport of injured rabbit lungs in two different states of recruitment.

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