Meeting Banner
Abstract #5062

Susceptibility Contrast at Ultra-low Magnetic field with Superparamagnetic Nanoparticles

David E. J. Waddington1,2, Thomas Boele2,3, Richard Maschmeyer1, Zdenka Kuncic1, and Matthew S. Rosen2,4,5

1Institute of Medical Physics, The University of Sydney, Sydney, Australia, 2A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3ARC Centre of Excellence for Engineered Quantum Systems, The University of Sydney, Sydney, Australia, 4Department of Physics, Harvard University, Cambridge, MA, United States, 5Harvard Medical School, Boston, MA, United States

MRI scanners operating at ultra-low fields (ULF) promise to reduce the cost and expand the clinical accessibility of MRI. Here, we use an ULF (6.5 mT) MRI scanner and an efficient balanced steady-state free precession MRI protocol to image superparamagnetic iron oxide nanoparticles (SPIONS) in solution. We observe strong susceptibility effects due to the highly-magnetized state of SPIONs even at ULF. These susceptibility effects enable the most sensitive imaging of a contrast agent at ULF that we are aware of. These results will broaden the clinical applications of ULF MRI, and have implications for drug tracking and delivery in nanotheranostics.

This abstract and the presentation materials are available to members only; a login is required.

Join Here