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Abstract #0003

MRI Cine-Tagging of Cardiac-Induced Motion for Noninvasive Staging of Liver Fibrosis

Thierry Lefebvre1,2,3, Léonie Petitclerc1,2,4, Mélanie Hébert1,2, Laurent Bilodeau1,2, Giada Sebastiani5, Damien Olivié1, Zu-Hua Gao6, Marie-Pierre Sylvestre2,7, Guy Cloutier1,8,9, Bich N Nguyen10, Guillaume Gilbert1,11, and An Tang1,2,8
1Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, 2Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, 3Medical Physics Unit, McGill University, Montréal, QC, Canada, 4C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, Netherlands, 5Department of Medicine, Division of Gastroenterology and Hepatology, McGill University Health Centre (MUHC), Montreal, QC, Canada, 6Department of Pathology, McGill University, Montreal, QC, Canada, 7Department of Social and Preventive Medicine, École de santé publique de l’Université de Montréal (ESPUM), Montreal, QC, Canada, 8Institute of Biomedical Engineering, Université de Montréal, Montreal, QC, Canada, 9Laboratory of Biorheology and Medical Ultrasonics (LBUM), Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, Canada, 10Service of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada, 11MR Clinical Science, Philips Healthcare Canada, Montreal, QC, Canada

MR elastography techniques for staging liver fibrosis assess the right liver and require additional hardware. MRI cine-tagging evaluates the strain of liver tissue and shows promise for staging liver fibrosis without additional hardware. It can be performed routinely during MRI examinations. Strain showed high correlation with fibrosis stages (ρ = -0.68, P < 0.0001). AUC was 0.81 to distinguish fibrosis stages F0 vs. ≥F1, 0.84 for ≤F1 vs. ≥F2, 0.86 for ≤F2 vs. ≥F3, and 0.87 for ≤F3 vs. F4. It could be used to assess the left liver lobe as a complement to MR elastography assessing the right lobe.

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