Abstract #0003

MRI Cine-Tagging of Cardiac-Induced Motion for Noninvasive Staging of Liver Fibrosis

Thierry Lefebvre^1,2,3, Léonie Petitclerc^1,2,4, Mélanie Hébert^1,2, Laurent Bilodeau^1,2, Giada Sebastiani⁵, Damien Olivié¹, Zu-Hua Gao⁶, Marie-Pierre Sylvestre^2,7, Guy Cloutier^1,8,9, Bich N Nguyen¹⁰, Guillaume Gilbert^1,11, and An Tang^1,2,8

¹Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, ²Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, ³Medical Physics Unit, McGill University, Montréal, QC, Canada, ⁴C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, Netherlands, ⁵Department of Medicine, Division of Gastroenterology and Hepatology, McGill University Health Centre (MUHC), Montreal, QC, Canada, ⁶Department of Pathology, McGill University, Montreal, QC, Canada, ⁷Department of Social and Preventive Medicine, École de santé publique de l’Université de Montréal (ESPUM), Montreal, QC, Canada, ⁸Institute of Biomedical Engineering, Université de Montréal, Montreal, QC, Canada, ⁹Laboratory of Biorheology and Medical Ultrasonics (LBUM), Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, Canada, ¹⁰Service of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada, ¹¹MR Clinical Science, Philips Healthcare Canada, Montreal, QC, Canada

MR elastography techniques for staging liver fibrosis assess the right liver and require additional hardware. MRI cine-tagging evaluates the strain of liver tissue and shows promise for staging liver fibrosis without additional hardware. It can be performed routinely during MRI examinations. Strain showed high correlation with fibrosis stages (ρ = -0.68, P < 0.0001). AUC was 0.81 to distinguish fibrosis stages F0 vs. ≥F1, 0.84 for ≤F1 vs. ≥F2, 0.86 for ≤F2 vs. ≥F3, and 0.87 for ≤F3 vs. F4. It could be used to assess the left liver lobe as a complement to MR elastography assessing the right lobe.

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