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Abstract #0009

Comparison between blood-brain barrier permeability to water and gadolinium-based contrast agents in an elderly cohort

Xingfeng Shao1, Samantha Jenny Ma1, and Danny JJ Wang1,2
1Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Department of Neurology, University of Southern California, Los Angeles, CA, United States

A diffusion-weighted arterial spin labeling (DW-ASL) technique has been proposed to non-invasively measure water exchange rate (kw) across the BBB. kw was compared with GBCAs permeability (Ktrans) in aged subjects at risk of small vessel disease. A positive correlation was found between kw and Ktrans only in the caudate, suggesting different BBB mechanisms probed by kw and Ktrans. Significant increase of kw was found in subjects with diabetes or high vascular risk while no Ktrans difference was observed. Water permeability could be a sensitive biomarker to study glymphatic function and vascular diseases before detectable BBB disruption occurs.

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