Circumventricular organs (CVOs), located around the ventricles without blood-brain barrier, maintain homeostasis between the blood, cerebrospinal fluid, and brain. Secretory CVOs are involved in peptide release and sensory CVOs regulate signal transmission. These organs can be an entrance point for pathogens. For the first time, physiological properties of the CVOs were assessed in vivo with dynamic contrast-enhanced (DCE) MRI.
Assessing pharmacokinetics (leakage rate; blood perfusion; uptake capacity/retention) with DCE MRI in 20 healthy males, demonstrated that only secretory CVOs had noticeable stronger hemodynamics and higher permeability than normal-appearing brain matter.