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Abstract #0014

Gd3+ Deposition as an Underestimated Hazard? – Potential Masking of Gadolinium Long-Term Deposition in Biological Regimes

Patrick Werner1,2, Patrick Schuenke1, Antje Ludwig3, Daria Dymnikova4, Christian Teutloff4, Matthias Taupitz5, and Leif Schröder1
1Leibniz-Forschungsinstitut fuer Molekulare Pharmakologie (FMP), Berlin, Germany, 2BIOphysical Quantitative Imaging Towards Clinical Diagnosis (BIOQIC), Berlin, Germany, 3Center for Cardiovascular Research (CCR), Charite Berlin, Berlin, Germany, 4Freie Universität Berlin, Berlin, Germany, 5Department of Radiology, Charite Berlin, Berlin, Germany

Gd3+-ions can be released from GBCAs after in vivo application and polysaccharides like glycosaminoglycans are candidates for binding of released Gd3+-ions by acting as competing chelators. We showed that the chelation of Gd3+-ions to polysaccharides cause an increase of R1 due to the high relaxivity of such complexes. However, at high GAG/Gd3+ ratios and in cell experiments, we observed a decrease of R1 after the chelation of Gd3+. Our results demonstrate the importance of more in vivo-like setups for the investigation of gadolinium transchelation processes to prevent an underestimation of the amount of deposited gadolinium in biological tissues.

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