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Abstract #0015

Distribution of intraperitoneally administered D2O in AQP4-knockout mouse brain after MCA occlusion

Obata Takayuki1, Takuya Urushihata1, Manami Takahashi1, Sayaka Shibata1, Nobuhiro Nitta1, Jeff Kershaw1, Yasuhiko Tachibana1, Masato Yasui2, Ichio Aoki1, Tatsuya Higashi1, Makoto Higuchi1, and Hiroyuki Takuwa1
1National Institute of Radiological Sciences, QST, Chiba, Japan, 2Department of Pharmacology, Keio University School of medicine, Tokyo, Japan

Using dynamic PDWI after intraperitoneal D2O injection, we observed a difference in the D2O distribution between aquaporin-4 knockout (AQP4-ko) and wild type (Wild) mice with MCA occlusion. The results suggest that blood flow changes and cell membrane water permeability have a complex relationship.

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