Abstract #0015

Distribution of intraperitoneally administered D2O in AQP4-knockout mouse brain after MCA occlusion

Obata Takayuki¹, Takuya Urushihata¹, Manami Takahashi¹, Sayaka Shibata¹, Nobuhiro Nitta¹, Jeff Kershaw¹, Yasuhiko Tachibana¹, Masato Yasui², Ichio Aoki¹, Tatsuya Higashi¹, Makoto Higuchi¹, and Hiroyuki Takuwa¹

¹National Institute of Radiological Sciences, QST, Chiba, Japan, ²Department of Pharmacology, Keio University School of medicine, Tokyo, Japan

Using dynamic PDWI after intraperitoneal D2O injection, we observed a difference in the D2O distribution between aquaporin-4 knockout (AQP4-ko) and wild type (Wild) mice with MCA occlusion. The results suggest that blood flow changes and cell membrane water permeability have a complex relationship.

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