Ferumoxytol—a safe, superparamagnetic iron oxide nanoparticle that amplifies T2* dephasing in blood vessels—can be used as a powerful image contrast enhancement agent to aid vascular imaging. Combining this with an innovative vascular segmentation tool, here we evaluate how Ferumoxytol improves vascular detection throughout the brain using a region-based analysis of the gray-matter and a bundle-specific analysis of the white-matter. We report increases in white-matter vasculature specificity and uncover spatial patterns similar to white-matter tracts, therefore this work sheds new light on the possible existence and influence of a concurrent network of vasculature that follows the known fiber bundles.
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