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Abstract #0016

Human cerebral white-matter vasculature imaged using the blood-pool contrast agent Ferumoxytol: bundle-specific vessels and vascular density

Michaël Bernier1,2, Olivia Viessmann1,2, Ned Ohringer1, Jingyuan E. Chen1,2, Nina E. Fultz1,3, Rebecca Karp Leaf4, Lawrence L. Wald1,2,5, and Jonathan R. Polimeni1,2,5
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Engineering, Boston University, Boston, MA, United States, 4Division of Hematology, Massachusetts General Hospital, Boston, MA, United States, 55Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States

Ferumoxytol—a safe, superparamagnetic iron oxide nanoparticle that amplifies T2* dephasing in blood vessels—can be used as a powerful image contrast enhancement agent to aid vascular imaging. Combining this with an innovative vascular segmentation tool, here we evaluate how Ferumoxytol improves vascular detection throughout the brain using a region-based analysis of the gray-matter and a bundle-specific analysis of the white-matter. We report increases in white-matter vasculature specificity and uncover spatial patterns similar to white-matter tracts, therefore this work sheds new light on the possible existence and influence of a concurrent network of vasculature that follows the known fiber bundles.

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