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Abstract #0017

Differences in quantitative glioma perfusion imaging with ASL and DSC: validation with 15O-H2O PET

Jan Petr1, Niels Verburg2, Joost P.A. Kuijer3, Thomas Koopman3, Vera C. Keil4, Esther A.H. Warnert5, Frederik Barkhof3,6, Jörg van den Hoff1, Ronald Boellaard3, Philip C. de Witt Hamer2, and Henri J.M.M. Mutsaerts3,7
1Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 2Neurosurgical Center Amsterdam, Amsterdam University Medical Center, location VU, Amsterdam, Netherlands, 3Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, location VU, Amsterdam, Netherlands, 4Department of Neuroradiology, Bonn University Hospital, Bonn, Germany, 5Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands, 6UCL Institutes of Neurology and Healthcare Engineering, London, United Kingdom, 7Ghent Institute for Functional and Metabolic Imaging (GIfMI), Ghent University, Ghent, Belgium

While agreement between ASL, DSC, and PET perfusion is well established in healthy volunteers, an analogous comparison in gliomas is still missing and more challenging. We compared ASL and DSC perfusion measurements with the gold-standard of 15O-H2O-PET perfusion measurements in eight patients diagnosed with gliomas. We showed the importance of normalization to the contralateral hemisphere, and identified several examples of different regional perfusion as assessed with ASL and DSC and interpreted them using the PET reference.

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