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Abstract #0018

Exploring label dynamics of velocity selective arterial spin labeling in the kidney

Isabell K. Bones1, Suzanne L. Franklin1,2, Anita A. Harteveld1, Matthias J.P. van Osch2, Sophie Schmid2, Jeroen Hendrikse3, Chrit Moonen1, Marijn van Stralen1, and Clemens Bos1
1Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 2C.J.Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

VSASL for renal application has constraints on the cut-off velocity, as low Vc in the presence of respiratory motion causes spurious labeling of moving tissue. With higher Vc, label could be generated more upstream in the vascular tree, potentially introducing ATT sensitivity. To study label dynamics of renal VSASL using a Vc compatible with free-breathing (Vc of 10cm/s), data at multiple time points were acquired. High ASL signal was already observed at early time points, thus supporting that spatially non-selective VSASL in the kidney generates label close to, or even inside the target tissue, also using a free-breathing compatible Vc.

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