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Abstract #0019

Multi-organ comparison of flow-based Arterial Spin Labeling techniques: brain and kidney perfusion imaging without transit time artefacts

Suzanne L. Franklin1,2,3, Isabell K. Bones2, Anita A. Harteveld2, Lydiane Hirschler1, Marijn van Stralen2, Anneloes de Boer2, Hans Hoogduin2, Matthias J.P. van Osch1,3, Sophie Schmid1,3, and Clemens Bos2
1C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, 3Leiden Institute for Brain and Cognition, Leiden University, Leiden, Netherlands

Different flow-based arterial spin labeling (ASL)-techniques were proposed in recent years. In this multi-organ study four flow-based ASL-techniques were compared, with pCASL in brain, and with both pCASL and FAIR in kidney. ASL-techniques were compared based on temporal-SNR, sensitivity to perfusion changes (in brain) and robustness to respiratory motion (in kidney). In brain, Velocity-Selective Inversion showed superior temporal-SNR and sensitivity to perfusion changes. In kidney, flow-based ASL-techniques showed decreased temporal-SNR compared to FAIR, although their settings can be improved to increase robustness to B1-inhomogeneity. All ASL-techniques were relatively robust to respiratory motion, showing potential for free-breathing kidney-ASL at 3T.

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