Different flow-based arterial spin labeling (ASL)-techniques were proposed in recent years. In this multi-organ study four flow-based ASL-techniques were compared, with pCASL in brain, and with both pCASL and FAIR in kidney. ASL-techniques were compared based on temporal-SNR, sensitivity to perfusion changes (in brain) and robustness to respiratory motion (in kidney). In brain, Velocity-Selective Inversion showed superior temporal-SNR and sensitivity to perfusion changes. In kidney, flow-based ASL-techniques showed decreased temporal-SNR compared to FAIR, although their settings can be improved to increase robustness to B1-inhomogeneity. All ASL-techniques were relatively robust to respiratory motion, showing potential for free-breathing kidney-ASL at 3T.
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