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Abstract #0022

Regional and depth dependence of cortical blood-flow assessed with high-resolution Arterial Spin Labeling

Manuel Taso1, Fanny Munsch1, Li Zhao2, and David C. Alsop1
1Division of MRI research, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2Diagnostic Imaging and Radiology, Children's National Medical Center, Washington, DC, United States

Imaging cortical blood-flow using ASL is relevant to unravel the basis of brain functional autoregulation or response to stimuli, but challenging because of the usual compromise between brain coverage, SNR and spatial resolution in ASL. We here propose to push the limits of volumetric ASL resolution using sparse variable-density FSE and Compressed-Sensing to study the distribution of cortical flow in healthy volunteers. We show through a group surface-based analysis some regional variations in cortical flow, but also depth-dependence of cortical flow. We also propose a high-resolution average ASL perfusion-weighted template that could have benefits for large-scale group studies.

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