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Abstract #0023

High-resolution whole brain ASL perfusion imaging at 7T with 12-fold acceleration and spatial-temporal regularized reconstruction

Xingfeng Shao1, Stefan M Spann2, Kai Wang1, Lirong Yan1,3, Stollberger Rudolf2, and Danny JJ Wang1,3
1Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, 2Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 3Department of Neurology, University of Southern California, Los Angeles, CA, United States

Ultra-high field allows ASL to achieve higher spatial resolution due to increased SNR and prolonged T1 relaxation. We present a single-shot 3D GRASE pCASL technique with 12-fold acceleration using time-dependent 2D CAIPI sampling strategy, and reconstruction of the label/control time series with joint spatial and temporal total-generalized-variation (TGV) regularization. 2D CAIPI under-sampling pattern increases temporal incoherence between measurements which allows joint reconstruction of the highly accelerated ASL time series. Combining the advantages of ultra-high field strength, pTx coils, accelerated acquisition and advanced reconstruction, whole-brain CBF map with 2 mm isotropic resolution was obtained within 5 mins.

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