Abstract #0023

High-resolution whole brain ASL perfusion imaging at 7T with 12-fold acceleration and spatial-temporal regularized reconstruction

Xingfeng Shao¹, Stefan M Spann², Kai Wang¹, Lirong Yan^1,3, Stollberger Rudolf², and Danny JJ Wang^1,3

¹Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Institute of Medical Engineering, Graz University of Technology, Graz, Austria, ³Department of Neurology, University of Southern California, Los Angeles, CA, United States

Ultra-high field allows ASL to achieve higher spatial resolution due to increased SNR and prolonged T1 relaxation. We present a single-shot 3D GRASE pCASL technique with 12-fold acceleration using time-dependent 2D CAIPI sampling strategy, and reconstruction of the label/control time series with joint spatial and temporal total-generalized-variation (TGV) regularization. 2D CAIPI under-sampling pattern increases temporal incoherence between measurements which allows joint reconstruction of the highly accelerated ASL time series. Combining the advantages of ultra-high field strength, pTx coils, accelerated acquisition and advanced reconstruction, whole-brain CBF map with 2 mm isotropic resolution was obtained within 5 mins.

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