Pseudo-continuous arterial spin labeling (PCASL) is very sensitive to off-resonance effects. This is especially a problem at higher fields (>3T). Off-resonance effects can be compensated by using an average or a vessel-specific correction integrated into the PCASL tagging/control pulse. Vessel-specific corrections can be performed using a prescan or a field map. In this study, we compared three off-resonance compensation strategies at 7T. Data showed that a large improvement (> 2 times) of the PCASL signal can be obtained with subject specific off-resonance correction with all 3 methods. The field map based method showed slightly better performance over the others.
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