A new scheme of water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST) MRI was proposed for non-invasive assessment of blood-brain-barrier (BBB) permeability to water. In this scheme, venous bolus-arrival-time was measured first by Look-Locker WEPCAST and then applied to single-delay long-labeling-duration WEPCAST scan to estimate water extraction fraction. The results showed an improved accuracy for estimation of BBB permeability.
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