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Abstract #0032

Assessing Repeatability of Blood Brain Barrier Permeability Measure Using Contrast-free MRI

Amnah Mahroo1, Nora-Josefin Breutigam1, and Matthias Günther1,2
1MR Physics, Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany, 2MR-Imaging and Spectroscopy, University of Bremen, Bremen, Germany

Disrupted blood brain barrier (BBB) is reported to be one of the causes in various neuropathological diseases1. We assessed the quantified permeability of BBB using blood to tissue water exchange dynamics by employing multi-echo ASL sequence in five healthy individuals. A repeated measurement was conducted to assess the robustness and precision of the method. The average gray matter values were 357 ± 62 ms which are in-accordance with the literature reported values.

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