Abstract #0033

Water exchange across blood-brain barrier is associated with CSF Amyloid-β 42 and cognition in healthy older adults

Xingfeng Shao¹, Brian T Gold², and Danny JJ Wang^1,3

¹Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States, ²Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, United States, ³Department of Neurology, University of Southern California, Los Angeles, CA, United States

Abnormally low CSF amyloid-β (Aβ)-42 level is an early biomarker of the Alzheimer’s Disease (AD), however lumbar puncture is required to collect CSF samples. A diffusion prepared arterial spin labeling technique was proposed to measure blood-brain barrier (BBB) water permeability (kw) non-invasively. Associations between water permeability and CSF Aβ42 levels in the “healthy” aging brains were studied. Significant positive correlations were found between kw and CSF Aβ42 and digit symbol scores, which suggests kw may serve as an early imaging marker of AD.

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