Abstract #0038

Comparison of mFFE & Axial T2-Weighted Fast-Spin-Echo Sequences for Lesion Detection in Low-Disability Multiple Sclerosis Patients

Mereze Visagie¹, Atlee Witt¹, Sanjana Satish¹, Shekinah Malone², Anna Combes¹, Kristin P O'Grady^1,3, Dylan Lawless^1,4, Francesca Bagnato⁵, Colin McKnight³, and Seth A Smith^1,3

¹Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ²Meharry Medical College, Nashville, TN, United States, ³Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁵Clinical Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

In multiple sclerosis (MS), detection of lesions in the spinal cord with MRI is important for diagnosis and monitoring of disease progression. Despite improved clinical MRI sequences, motion and pulsation artifact remain a challenge for small lesion identification. We sought to compare sensitivity for lesion detection between multi-echo gradient echo (mFFE) and T2-weighted fast-spin-echo (T2-FSE) sequences at 3T in 16 relapsing-remitting MS patients with low disability. By comparing lesion fraction and average lesion burden, we demonstrated that mFFE has greater sensitivity for spinal cord lesions than T2-FSE.

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