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Abstract #0039

A comparison of phase image and quantitative susceptibility mapping in identifying inflammation in  chronic multiple sclerosis lesions

Xianfu Luo1,2, Ulrike W. Kaunzner3, Thanh D. Nguyen1, Yeona Kang4, Elizabeth Sweeney5, Weiyuan Huang1, Yi Wang1, and Susan Gauthier3
1Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States, 2Department of Radiology, Northern Jiangsu People's Hospital, Yangzhou, China, 3Department of Neurology, Weill Medical College of Cornell University, New York, NY, United States, 4Department of Radiology/Nuclear Medicine, Weill Medical College of Cornell University, New York, NY, United States, 5Department of Healthcare Policy and Research, Weill Medical College of Cornell University, New York, NY, United States

Both MR phase imaging and quantitative susceptibility mapping (QSM) are used to assess the presence of chronic active multiple sclerosis lesions. It is important to evaluate which measure can detect ongoing inflammation in chronic active lesions most accurately. This study combined PK11195-PET with QSM versus phase imaging, and demonstrated that QSM can detected higher uptake of PK11195, as compared to phase imaging.

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