Abstract #0043

C5 level area can replace whole cervical spinal cord area measurements in multiple sclerosis as a practical biomarker of progression

Burcu Zeydan^1,2, Selen Ucem^2,3, Tsemacha Dubuche⁴, Shila Azodi⁴, Govind Bhagavatheeshwaran^4,5, Jan-Mendelt Tillema ², John Port¹, Daniel Reich⁵, Steven Jacobson⁴, Kejal Kantarci¹, and Orhun H. Kantarci²

¹Radiology, Mayo Clinic, Rochester, MN, United States, ²Neurology, Mayo Clinic, Rochester, MN, United States, ³Marmara University School of Medicine, Istanbul, Turkey, ⁴Viral Immunology Section, Neuroimmunology and Neurovirology Division, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States, ⁵Translational Neuroradiology Section, Neuroimmunology and Neurovirology Division, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States

Subclinical progression reflecting neurodegeneration can be measured and followed through spinal cord volume monitoring in multiple sclerosis (MS). The increased atrophy is reflected more prominently in the caudal cervical spinal cord segment. In this study, we identified the C5 level area measurement which can reflect whole cervical spinal cord area in patients with MS using both semi-automated and manual measurements. We propose that the C5 level area measurement can replace whole cervical spinal cord area measurement in MS as a more practical biomarker of progression.

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