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Abstract #0043

C5 level area can replace whole cervical spinal cord area measurements in multiple sclerosis as a practical biomarker of progression

Burcu Zeydan1,2, Selen Ucem2,3, Tsemacha Dubuche4, Shila Azodi4, Govind Bhagavatheeshwaran4,5, Jan-Mendelt Tillema 2, John Port1, Daniel Reich5, Steven Jacobson4, Kejal Kantarci1, and Orhun H. Kantarci2
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Neurology, Mayo Clinic, Rochester, MN, United States, 3Marmara University School of Medicine, Istanbul, Turkey, 4Viral Immunology Section, Neuroimmunology and Neurovirology Division, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States, 5Translational Neuroradiology Section, Neuroimmunology and Neurovirology Division, National Institute of Neurological Disorders and Stroke, Bethesda, MD, United States

Subclinical progression reflecting neurodegeneration can be measured and followed through spinal cord volume monitoring in multiple sclerosis (MS). The increased atrophy is reflected more prominently in the caudal cervical spinal cord segment. In this study, we identified the C5 level area measurement which can reflect whole cervical spinal cord area in patients with MS using both semi-automated and manual measurements. We propose that the C5 level area measurement can replace whole cervical spinal cord area measurement in MS as a more practical biomarker of progression.

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