Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system, with MRI routinely performed for brain but often neglected in spinal cord. When cord imaging IS performed, atrophy is usually assessed at the C2/3 segment. We aimed to validate cord cross-sectional-area (CSA) measurements using T1-weighted whole-brain images. In controls, strong correlations were seen between C1 CSA from cord and brain images, and between C1 and C2/3 CSA from cord images.
In MS, C1 CSA from brain images and C2/3 CSA from cord images correlated. We showed that metrics obtained from brain images could provide relevant cord atrophy measures.