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Abstract #0045

Differences in cortical and white matter myelination: a challenge for MRI myelin biomarkers.

Evgeniya Kirilina1,2, Ilona Lipp1, Carsten Jäger1, Markus Morawski3, Merve N. Terzi4,5, Hans-Jürgen Bidmon6, Markus Axer4, Pitter F. Huesgen5, and Nikolaus Weiskopf1,7,8
1Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Center for Computational Neuroscience, Free University Berlin, Berlin, Germany, 3Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany, 4Institute of Neuroscience and Medicine, Forschungszentrum Jülich, Juelich, Germany, 5Zentralinstitut für Engineering, Elektronik und Analytik, Forschungszentrum Jülich, Juelich, Germany, 6C. und O. Vogt-Instituts für Hirnforschung, Heinrich-Heine-Universität Düsseldorf, Duesseldorf, Germany, 7Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany, 8Wellcome Centre for Human Neuroimaging, University College London, London, United Kingdom

Quantitative MRI parameters in the brain provide unique information on tissue myelination. However, the validation studies performing quantitative comparisons between MRI metrics and tissue myelin content are very limited, mainly due to the to the lack of methods for histological myelin quantification. Here, we explore lipid imaging using matrix-assisted laser desorption/ionization (MALDI) and multiple histological myelin stains in post-mortem human brain tissue samples for validation of MRI based myelin biomarkers. We show that tissue lipid composition vary across different cortical layers and white matter pathways, potentially reflecting differences in myelin structure and may impact MRI-based myelination metrics.

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