Microstructural parameters of the brain such as the myelin concentration or g-ratio (average ratio between axonal and fiber diameter) can provide important information on the pathophysiology of demyelinating diseases. Several myelin sensitive MRI methods exist. However, correlations between different myelin sensitive measures and the best choice for g-ratio mapping is not yet fully explored. Therefore, we compared MWF, ihMTR, and MTsat in white matter and found the highest correlation between MWF and ihMTR. Those measures also varied more strongly across WM regions compared to MTsat, which suggests that they could be more reliable for further analyses such as g-ratio imaging.
This abstract and the presentation materials are available to members only; a login is required.