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Abstract #0046

Towards advanced microstructural analyses of white matter: Quantitative regional comparison of different myelin measures

Ronja Berg1, Aurore Menegaux1, Guillaume Gilbert2, Claus Zimmer1, Christian Sorg1, Irene Vavasour3, and Christine Preibisch1
1School of Medicine, Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2MR Clinical Science, Philips Healthcare, Markham, ON, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada

Microstructural parameters of the brain such as the myelin concentration or g-ratio (average ratio between axonal and fiber diameter) can provide important information on the pathophysiology of demyelinating diseases. Several myelin sensitive MRI methods exist. However, correlations between different myelin sensitive measures and the best choice for g-ratio mapping is not yet fully explored. Therefore, we compared MWF, ihMTR, and MTsat in white matter and found the highest correlation between MWF and ihMTR. Those measures also varied more strongly across WM regions compared to MTsat, which suggests that they could be more reliable for further analyses such as g-ratio imaging.

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