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Abstract #0052

Myelin water imaging is sensitive to white matter fiber orientation in the human brain

Christoph Birkl1,2, Jonathan Doucette1,3, Enedino Hernández-Torres1, and Alexander Rauscher1,3,4
1UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2Department of Neurology, Medical University of Graz, Graz, Austria, 3Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 4Department of Pediatrics (Division of Neurology), University of British Columbia, Vancouver, BC, Canada

We demonstrated that the measurement of MWF is considerably influenced by the angle between the white matter fiber tracts and the main magnetic field. Furthermore, we showed that the traditionally used cut-off between myelin water and intra- and extracellular water of 40 ms overestimates MWF.

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