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Abstract #0053

Quantitative myelin imaging in the ferret brain for traumatic brain injury research 

JP Galons1, Kevin Harkins2, Mark Does2, Theodore Trouard1, and Elizabeth Hutchinson1
1University of Arizona, Tucson, AZ, United States, 2Vanderbilt University, Nashville, TN, United States

MRI tools for mapping myelin content could provide useful markers of injury and repair in neurologic disorders that preferentially affect white matter such as traumatic brain injury (TBI). In this study, we apply two novel myelin water mapping approaches - bound pool fraction (BPF) from selective inversion recovery MRI and myelin water fraction (MWF) from multiple spin echo MRI - in the ex-vivo ferret brain with and without injury in order to develop these myelin mapping markers for pre-clinical TBI research. We demonstrate high quality BPF and MWF maps and describe metric behavior in a region of focal injury.

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