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Abstract #0054

Longitudinal changes of myelin water fraction during the first year after moderate to severe diffuse traumatic brain injury

Joon Yul Choi1, John Whyte2, Amanda R Rabinowitz2, Vincent L Chow3, Se-Hong Oh4, Jongho Lee5, and Junghoon J Kim3
1Epilepsy Center / Neurological Institute, Cleveland Clinic, Cleveland, OH, United States, 2Moss Rehabilitation Research Institute, Elkins Park, PA, United States, 3Department of Molecular, Cellular, and Biomedical Sciences, CUNY School of Medicine, The City College of New York, New York, NY, United States, 4Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea, Republic of, 5Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Institute of Engineering Research, Seoul National University, Seoul, Korea, Republic of

Reliable MRI biomarkers of white matter degeneration can be useful for monitoring post-traumatic progressive neurodegeneration and identifying potential treatment targets. We report that myelin water signal can be measured reliably during the first year after moderate to severe traumatic axonal injury. We also report that apparent myelin water fraction from the whole brain white matter continued to decrease beyond 3 months post-injury, reflecting progressive axonal degeneration and demyelination.

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