Abstract #0057

Closer look at Multiple Sclerosis lesions: an initial result of Positive and Negative Magnetic Susceptibility Separation

Jinhee Jang¹, Hyeong-geol Shin², Yoonho Nam^1,3, Jingu Lee², Jongho Lee², and Woojun Kim⁴

¹Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, ²Department of Electrical and Computer Engineering, Seoul National University, Seoul, Republic of Korea, ³Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, ⁴Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

While susceptibility contrast gives details for MS lesions, two major changes – iron deposition and de-myelination had same contribution on QSM, increasing bulk magnetic susceptibility. In this work, we applied separation of positive and negative sources in clinical MS patients, and had a closer look of in-vivo MS lesions. We demonstrate variable appearances of MS lesions on separation maps as well as conventional imaging and QSM, and complex distribution and dynamic changes of positive (i.e. iron) and negative (i.e. myelin) in MS lesions, in cross-sectional and longitudinal observations.

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