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Abstract #0065

Virtual hypoxia and structural network alterations in multiple sclerosis: a combined 23Na and diffusion MRI study

Adil Maarouf1,2, Hanna Bou Ali1, Pierre Besson1, Jan Patrick Stellman1,3, Soraya Gherib1, Fanelly Pariollaud1, Arnaud Le Troter1, Maxime Guye1,3, Patrick Viout1, Jean Pelletier1,2, Jean-Philippe Ranjeva1, Bertrand Audoin1,2, and Wafaa Zaaraoui1
1Aix-Marseille Université, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France, 3APHM, Hôpital de la Timone, Pôle d’Imagerie Médicale, CEMEREM, Marseille, France

Virtual hypoxia is a key factor in the induction of pathological processes in multiple sclerosis. 23Na-MRI is an emerging technique in virtual hypoxia exploration, with previous studies showing relevance of grey matter sodium accumulation in MS. In the present study, we showed that grey matter sodium accumulation is mainly driven by accumulation in the most connected cortical regions (called hubs) and correlate with disability. This study provides an insight in several processes of energy failure and brain reorganization in MS.

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