Abstract #0064

Regional oxygen extract fraction mapping (rOEF) of multiple sclerosis brains

Junghun Cho¹, Thanh D. Nguyen², Weiyuan Huang², Shun Zhang², Xianfu Luo², Susan A. Gauthier³, Pascal Spincemaille², Ajay Gupta², and Yi Wang^1,2

¹Biomedical Engineering, Cornell University, New York, NY, United States, ²Radiology, Weill Cornell Medical College, New York, NY, United States, ³Neurology, Weill Cornell Medical College, New York, NY, United States

Impaired energy metabolism is a major contributor to the ongoing inflammation and neurodegeneration in multiple sclerosis (MS) brains, particularly MS lesions. Cerebral regional oxygen extraction fraction mapping (rOEF) obtained from challenge-free multiecho gradient echo data demonstrates that lesions identified on quantitative susceptibility mapping (QSM) without rim (QSM rim-) have heterogenous OEF that is higher than that in other type of lesions. rOEF may offer insight into MS lesion remylination viability.

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