Impaired energy metabolism is a major contributor to the ongoing inflammation and neurodegeneration in multiple sclerosis (MS) brains, particularly MS lesions. Cerebral regional oxygen extraction fraction mapping (rOEF) obtained from challenge-free multiecho gradient echo data demonstrates that lesions identified on quantitative susceptibility mapping (QSM) without rim (QSM rim-) have heterogenous OEF that is higher than that in other type of lesions. rOEF may offer insight into MS lesion remylination viability.
This abstract and the presentation materials are available to members only; a login is required.