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Abstract #0064

Regional oxygen extract fraction mapping (rOEF) of multiple sclerosis brains

Junghun Cho1, Thanh D. Nguyen2, Weiyuan Huang2, Shun Zhang2, Xianfu Luo2, Susan A. Gauthier3, Pascal Spincemaille2, Ajay Gupta2, and Yi Wang1,2
1Biomedical Engineering, Cornell University, New York, NY, United States, 2Radiology, Weill Cornell Medical College, New York, NY, United States, 3Neurology, Weill Cornell Medical College, New York, NY, United States

Impaired energy metabolism is a major contributor to the ongoing inflammation and neurodegeneration in multiple sclerosis (MS) brains, particularly MS lesions. Cerebral regional oxygen extraction fraction mapping (rOEF) obtained from challenge-free multiecho gradient echo data demonstrates that lesions identified on quantitative susceptibility mapping (QSM) without rim (QSM rim-) have heterogenous OEF that is higher than that in other type of lesions. rOEF may offer insight into MS lesion remylination viability.

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