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Abstract #0063

Short and long sodium concentrations in multiple sclerosis: a multi-echo ultra- high field 23Na MRI study

Mohamed Mounir El Mendili1, Ben Ridley1, Bertrand Audoin1,2, Soraya Gherib1, Lauriane Pini1, Françoise Reuter1,2, Maxime Guye1,3, Armin Nagel4, Audrey Rico2, Clémence Boutière2, Jean Pelletier1,2, Jean-Philippe Ranjeva1, Adil Maarouf1,2, and Wafaa Zaaraoui1
1Aix-Marseille Université, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France, 3APHM, Hôpital de la Timone, Pôle d’Imagerie Médicale, CEMEREM, Marseille, France, 4Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Alteration of sodium homeostasis was previously evidenced in multiple sclerosis with total sodium concentration (TSC) found to be related to disability. However, the correlations found were moderate, maybe due to the fact that measured sodium accumulation combined intra and extra cellular sodium signal while only intra-cellular sodium concentration is relevant to assess neurodegeneration. One may suppose that developing reliable sequences able to assess only the intra-cellular signal may lead to a better estimation of neurodegeneration in multiple sclerosis and better correlations with irreversible disability. The present study proposes an original multi-TE sequence at 7T to reach this goal.

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