Abstract #0063

Short and long sodium concentrations in multiple sclerosis: a multi-echo ultra- high field 23Na MRI study

Mohamed Mounir El Mendili¹, Ben Ridley¹, Bertrand Audoin^1,2, Soraya Gherib¹, Lauriane Pini¹, Françoise Reuter^1,2, Maxime Guye^1,3, Armin Nagel⁴, Audrey Rico², Clémence Boutière², Jean Pelletier^1,2, Jean-Philippe Ranjeva¹, Adil Maarouf^1,2, and Wafaa Zaaraoui¹

¹Aix-Marseille Université, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital de la Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, Marseille, France, ³APHM, Hôpital de la Timone, Pôle d’Imagerie Médicale, CEMEREM, Marseille, France, ⁴Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Alteration of sodium homeostasis was previously evidenced in multiple sclerosis with total sodium concentration (TSC) found to be related to disability. However, the correlations found were moderate, maybe due to the fact that measured sodium accumulation combined intra and extra cellular sodium signal while only intra-cellular sodium concentration is relevant to assess neurodegeneration. One may suppose that developing reliable sequences able to assess only the intra-cellular signal may lead to a better estimation of neurodegeneration in multiple sclerosis and better correlations with irreversible disability. The present study proposes an original multi-TE sequence at 7T to reach this goal.

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