Alteration of sodium homeostasis was previously evidenced in multiple sclerosis with total sodium concentration (TSC) found to be related to disability. However, the correlations found were moderate, maybe due to the fact that measured sodium accumulation combined intra and extra cellular sodium signal while only intra-cellular sodium concentration is relevant to assess neurodegeneration. One may suppose that developing reliable sequences able to assess only the intra-cellular signal may lead to a better estimation of neurodegeneration in multiple sclerosis and better correlations with irreversible disability. The present study proposes an original multi-TE sequence at 7T to reach this goal.
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