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Abstract #0062

In vivo proton exchange rate mapping is highly correlated with Gadolinium enhancement for staging Multiple Sclerosis Lesions

Weiwei Chen1, Mehran Shaghaghi2, Haiqi Ye1, Qianlan Chen1, Yan Zhang1, and Kejia Cai2,3,4
1Radiology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2Radiology, University of Illinois at Chicago, Chicago, IL, United States, 3Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, 4Bioengieering, University of Illinois at Chicago, Chicago, IL, United States

In this study, at the first time, we performed in vivo kex MRI of MS patients and evaluated its potential value for staging clinical MS lesions. In vivo proton exchange rate mapping was found to be highly correlated with Gadolinium enhancement for determining lesion activity. With further validation, kex may be an alternative endogenous MRI contrast for the clinical determination of dissemination in time (DIT) of MS lesions.

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