Abstract #0062

In vivo proton exchange rate mapping is highly correlated with Gadolinium enhancement for staging Multiple Sclerosis Lesions

Weiwei Chen¹, Mehran Shaghaghi², Haiqi Ye¹, Qianlan Chen¹, Yan Zhang¹, and Kejia Cai^2,3,4

¹Radiology, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ²Radiology, University of Illinois at Chicago, Chicago, IL, United States, ³Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ⁴Bioengieering, University of Illinois at Chicago, Chicago, IL, United States

In this study, at the first time, we performed in vivo k_ex MRI of MS patients and evaluated its potential value for staging clinical MS lesions. In vivo proton exchange rate mapping was found to be highly correlated with Gadolinium enhancement for determining lesion activity. With further validation, k_ex may be an alternative endogenous MRI contrast for the clinical determination of dissemination in time (DIT) of MS lesions.

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