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Abstract #0061

Lesions to the central and peripheral nervous system in multiple sclerosis are inversely correlated: A Study on magnetic resonance neurography 

Johann Malte Enno Jende1, Felix Tobias Kurz1, Mirjam Korporal-Kuhnke2, Markus Weiler2, Brigitte Wildemann2, Andrea Viehöver2, Sabine Heiland1, Wolfgang Wick2, Martin Bendszus1, and Jennifer Kollmer1
1Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 2Neurology, Heidelberg University Hospital, Heidelberg, Germany

This study investigated the correlation between T2w-hyperintense lesions to the peripheral nervous system (PNS) and the central nervous system (CNS) in multiple sclerosis (MS) by combining 3 Tesla magnetic resonance neurography (MRN) and 3 Tesla CNS MRI. It was found that CNS lesions and PNS lesions were inversely correlated (r=-0.432; p=0.0002). This finding might help to elucidate the underlying pathomechanism of PNS involvement in MS by indicating that PNS demyelination in MS does not occur secondary to CNS lesions in the sense of Wallerian degeneration.

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