Abstract #0061

Lesions to the central and peripheral nervous system in multiple sclerosis are inversely correlated: A Study on magnetic resonance neurography

Johann Malte Enno Jende¹, Felix Tobias Kurz¹, Mirjam Korporal-Kuhnke², Markus Weiler², Brigitte Wildemann², Andrea Viehöver², Sabine Heiland¹, Wolfgang Wick², Martin Bendszus¹, and Jennifer Kollmer¹

¹Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, ²Neurology, Heidelberg University Hospital, Heidelberg, Germany

This study investigated the correlation between T2w-hyperintense lesions to the peripheral nervous system (PNS) and the central nervous system (CNS) in multiple sclerosis (MS) by combining 3 Tesla magnetic resonance neurography (MRN) and 3 Tesla CNS MRI. It was found that CNS lesions and PNS lesions were inversely correlated (r=-0.432; p=0.0002). This finding might help to elucidate the underlying pathomechanism of PNS involvement in MS by indicating that PNS demyelination in MS does not occur secondary to CNS lesions in the sense of Wallerian degeneration.

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