Meeting Banner
Abstract #0060

Advanced MRI measures reveal sex differences in the Normal Appearing and Diffusely Abnormal White Matter of Multiple Sclerosis Brain

Irene Margaret Vavasour1,2, Carina Graf2,3, Shannon H Kolind1,2,3,4,5, Peng Sun6, Robert Carruthers4, Anthony Traboulsee4,5, GR Wayne Moore2,7, David KB Li1,4,5, and Cornelia Laule1,2,3,7
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada, 3Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 4Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, 5MS/MRI Research Group, University of British Columbia, Vancouver, BC, Canada, 6Radiology, Washington University, St. Louis, MO, United States, 7Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Diffusely abnormal white matter (DAWM) is a non-focal area of mildly increased signal on proton density and T2-weighted images. Advanced imaging techniques (T1 and T2 relaxation and diffusion basis spectrum imaging) compared measures of myelin, axons, oedema and inflammation between males and females with multiple sclerosis in normal appearing white matter (NAWM) and areas of DAWM. In NAWM, males had higher axial diffusivity indicative of axonal damage. In DAWM, MRI measures suggested demyelination in females whereas axonal damage was suggested in males. Both sexes show increased T1, GMT2 and water content in DAWM likely related to oedema.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here