Abstract #0059

Mapping temporal changes in myelin properties of newly formed Multiple Sclerosis lesions

Manoj K. Sammi¹, Elizabeth Silbermann², Greg Zarelli³, Dennis Bourdette², Michael Lane², Vijayshree Yadav², Caroline Butler⁴, Katherine Powers¹, Katherine Powers¹, Ian Tagge¹, Susan Goelz⁵, and William D Rooney^1,2,6,7

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Department of Neurology, Oregon Health & Science University, Portland, OR, United States, ³Kaiser Sunnyside Medical Center, Clackamas, OR, United States, ⁴Oregon Health & Science University, Portland, OR, United States, ⁵Myelin Repair Foundation, Saratoga, CA, United States, ⁶Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States, ⁷Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States

A novel MRI T₁ relaxometry technique is used to monitor myelin water fraction (MWF) in normal appearing white matter and multiple sclerosis lesions in subjects with newly formed white matter lesions at baseline and a follow-up study after six months. MWF was consistently low in new lesions at baseline and recovery over 6 months was highly variable. T₁ relaxometry provides a promising quantitative and non-invasive tool for studying myelin repair in human brain.

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