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Abstract #0059

Mapping temporal changes in myelin properties of newly formed Multiple Sclerosis lesions

Manoj K. Sammi1, Elizabeth Silbermann2, Greg Zarelli3, Dennis Bourdette2, Michael Lane2, Vijayshree Yadav2, Caroline Butler4, Katherine Powers1, Katherine Powers1, Ian Tagge1, Susan Goelz5, and William D Rooney1,2,6,7
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, 2Department of Neurology, Oregon Health & Science University, Portland, OR, United States, 3Kaiser Sunnyside Medical Center, Clackamas, OR, United States, 4Oregon Health & Science University, Portland, OR, United States, 5Myelin Repair Foundation, Saratoga, CA, United States, 6Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States, 7Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States

A novel MRI T1 relaxometry technique is used to monitor myelin water fraction (MWF) in normal appearing white matter and multiple sclerosis lesions in subjects with newly formed white matter lesions at baseline and a follow-up study after six months. MWF was consistently low in new lesions at baseline and recovery over 6 months was highly variable. T1 relaxometry provides a promising quantitative and non-invasive tool for studying myelin repair in human brain.

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