Abstract #0059

Mapping temporal changes in myelin properties of newly formed Multiple Sclerosis lesions

Manoj K. Sammi¹, Elizabeth Silbermann², Greg Zarelli³, Dennis Bourdette², Michael Lane², Vijayshree Yadav², Caroline Butler⁴, Katherine Powers¹, Katherine Powers¹, Ian Tagge¹, Susan Goelz⁵, and William D Rooney^1,2,6,7

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States, ²Department of Neurology, Oregon Health & Science University, Portland, OR, United States, ³Kaiser Sunnyside Medical Center, Clackamas, OR, United States, ⁴Oregon Health & Science University, Portland, OR, United States, ⁵Myelin Repair Foundation, Saratoga, CA, United States, ⁶Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, United States, ⁷Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, United States

A novel MRI T₁ relaxometry technique is used to monitor myelin water fraction (MWF) in normal appearing white matter and multiple sclerosis lesions in subjects with newly formed white matter lesions at baseline and a follow-up study after six months. MWF was consistently low in new lesions at baseline and recovery over 6 months was highly variable. T₁ relaxometry provides a promising quantitative and non-invasive tool for studying myelin repair in human brain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.