Transcranial direct current stimulation (tDCS) is an innovative, non-invasive, brain stimulation technique that modulates cortical excitability by applying weak electrical currents. Despite cognitive improvements in multiple sclerosis (MS) subjects have been recently reported, the underlying in-vivo physiological mechanism of tDCS remains largely unclear. The purpose of this study is therefore to firstly address the real time tDCS effect (with simultaneous MRI scans) on the functional connectivity of both controls and MS patients. Secondly, we want to investigate whether such changes are altered in MS subjects following 20 tDCS treatment sessions.
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