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Abstract #0086

Free-Breathing Volumetric Liver R2* Quantification in Pediatric Patients Using 3D Self-Gating Motion-Compensated Stack-of-Radial MRI

Xiaodong Zhong1, Houchun H Hu2, Tess Armstrong3,4, Marcel D Nickel5, Stephan A.R. Kannengiesser5, Vibhas Deshpande6, Berthold Kiefer5, and Holden H Wu3,4
1MR R&D Collaborations, Siemens Healthcare, Los Angeles, CA, United States, 2Department of Radiology, Nationwide Children's Hospital, Columbus, OH, United States, 3Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 4Department of Physics and Biology in Medicine, University of California Los Angeles, Los Angeles, CA, United States, 5MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 6MR R&D Collaborations, Siemens Healthcare, Austin, TX, United States

Liver fat and iron quantification is of growing interest. However, it is challenging and sometimes impossible to perform breath-hold MRI acquisitions in children. Using a breath-hold 3D Cartesian method as reference, a self-gating free-breathing 3D stack-of-radial liver R2* quantification technique was evaluated. Results showed that the free-breathing stack-of-radial technique accurately quantified fat even without self-gating, while free-breathing R2* quantification had biases caused by respiratory motion and self-gating was necessary for accurate R2* quantification in pediatric subjects. This technique has potential for accurate and efficient free-breathing quantification of both liver fat and iron in pediatric patients.

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